Fusion: Expensive and Taking Forever?

Temozolomide and MGMT forever?

Christian Ungermann: Taking apart vacuole fusion

T he yeast vacuole (similar to the lysosome in higher eukaryotes) is the recipient of cargo from both the secretory and endocytic pathways. Studies of this highly dynamic organelle have been crucial to our general understanding of intracellular transport, and Christian Ungermann continues to elucidate the many different steps of vacuole fusion and the proteins that regulate them. earned his PhD...

Forever Young

Propagation of a species requires periodic cell renewal to avoid clonal senescence. Liu et al. (2010) now describe a new mechanism of cell renewal in budding yeast, in which damaged protein aggregates are transported out of the daughter buds along actin cables to preserve youthfulness.

Revision Forever!

Revision is a method to deal with non-monotonic processes. It has been used in theory of truth an an answer to semantic paradoxes as the liar, but the idea is universal and resurfaces in many areas of logic and applications of logic. In this survey, we describe the general idea in the framework of pointer semantics and point out that beyond the formal semantics given by Gupta and Belnap, the pr...

Bricolage forever!

According to constructivism, learning takes place by constructing cognitive structures. An experiment was carried out to uncover the mental models of experienced, but not professional, users of a word processor. The study shows that the mental models are superficial, and that bricolage (trial-and-error) is extensively used even though it is not viable for solving nontrivial problems. The conclu...